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Progressive reorganization of mitochondrial apparatus in aging skeletal muscle of naked mole rats (Heterocephalus glaber) as revealed by electron microscopy: potential role in continual maintenance of muscle activityстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Vays V.B., Vangeli I.M., Eldarov C.M., Holtze S., Hildebrandt T.B., Bakeeva L.E., Skulachev V.P.
- Журнал: AGING-US
- Том: 13
- Номер: 22
- Год издания: 2021
- DOI: 10.18632/aging.203720
- Аннотация: The authors examined the ultrastructure of mitochondrial apparatus of skeletal muscles of naked mole rats(Heterocephalus glaber) from the age of 6 months to 11 years. The obtained results have demonstrated thatthe mitochondria in skeletal muscles of naked mole rats aged below 5 years is not well-developed andrepresented by few separate small mitochondria. Mitochondrial reticulum is absent. Starting from the age of 5years, a powerful mitochondrial structure are develop. By the age of 11 years, it become obvious that themitochondrial apparatus formed differs from that in the skeletal muscle of adult rats and mice, but resemblesthat of cardiomyocytes of rats or naked mole rats cardiomyocytes. From the age of 6 months to 11 years,percentage area of mitochondria in the skeletal muscle of naked mole rat is increasing by five times. Thegrowth of mitochondria is mainly driven by increased number of organelles. Such significant growth ofmitochondria is not associated with any abnormal changes in mitochondrial ultrastructure.We suppose that specific structure of mitochondrial apparatus developed in the skeletal muscle of naked molerats by the age of 11 years is necessary for continual skeletal muscle activity of these small mammals burrowingvery long holes in stony earth, resembling continual activity of heart muscle. In any case, ontogenesis of nakedmole rat skeletal muscles is much slower than of rats and mice (one more example of neoteny).
- Добавил в систему: Бакеева Лора Евгеньевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | aging-v13iundefined-203720.pdf | 35,6 МБ | 29 ноября 2021 [Saprunova] |