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DEVELOPMENT AND VALIDATION OF A METHOD FOR ASSAY OF THE ORIGINAL ANTITUBERCULOSIS AGENT THIOZONIDE IN PLASMA FOR PHARMACOKINETIC STUDIESстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 декабря 2016 г.
- Авторы: Ramenskaya G.V., Shokhin I.E., Men'shikova L.A., Savchenko A.Y., Smirnov V.V., Egorenkov E.A.
- Журнал: Pharmaceutical Chemistry Journal
- Том: 49
- Номер: 3
- Год издания: 2015
- Издательство: Kluwer Academic/Plenum Publishers
- Местоположение издательства: United States
- Первая страница: 199
- Последняя страница: 202
- DOI: 10.1007/s11094-015-1254-4
- Аннотация: A method for assaying the antituberculosis drug thiozonide in plasma was developed and validated. Sample preparation consisted of precipitation of proteins with acetonitrile. Assay was by HPLC with a mass-selective detector. The method developed here was validated in terms of the following validation properties: selectivity, linearity, accuracy, precision, quantitative detection limit, sample transfer, and solution stability. The analytical range of the method was 1 – 1000 ng/ml thiozonide in plasma. This analytical range allows this method to be used for further studies of the pharmacokinetics of the innovative drug thiozonide.
- Добавил в систему: Раменская Галина Владиславовна