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Study by optical techniques of the dependence of aggregation parameters of human red blood cells on their deformabilityстатья
Статья опубликована в журнале из списка RSCI Web of Science
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 8 апреля 2022 г.
- Авторы: Maslianitsyna Anastasia I., Ermolinsky Petr B., Lugovtsov Andrei E., Priezzhev Alexander V.
- Журнал: Journal of Biomedical Photonics & Engineering
- Том: 6
- Номер: 2
- Год издания: 2020
- Издательство: Samara National Research University
- Местоположение издательства: Samara
- Первая страница: 020305-1
- Последняя страница: 020305-6
- Номер статьи: 020305
- DOI: 10.18287/jbpe20.06.020305
- Аннотация: Blood microcirculation in human body is greatly dependent on the microrheologic properties of red blood cells. The aim of this work is to identify the relationship between the deformability of these cells and their aggregation properties, both of which are the key factors for the blood flow. Laser diffractometry, diffuse light scattering and laser tweezers were implemented for in vitromeasurements. Different osmolarity of plasma (150–500 mOsm/l) and concentrations of glutaraldehyde (up to 0.004%) were used to change the deformability of healthy red blood cells in vitro. The results show that with the cells becoming more rigid some aggregation parameters (e.g. the fraction of aggregated cells) decrease, while some of them (e.g. the hydrodynamic strength of the aggregate) stay unchanged. For example, after incubation in 0.004% glutaraldehyde solution the erythrocyte deformability drops by 19 ± 2% and this leads to a decrease by 77 ± 4% in the aggregation index. This means that there is a connection between cell deformability and the formation of the aggregates, however the relationship is less pronounced and more complex for the disaggregation process.
- Добавил в систему: Луговцов Андрей Егорович