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Properties and biological impact of RNA G-quadruplexes: from order to turmoil and backстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 октября 2021 г.
- Авторы: Kharel Prakash, Becker Gertraud, Tsvetkov Vladimir, Ivanov Pavel
- Журнал: Nucleic Acids Research
- Том: 48
- Номер: 22
- Год издания: 2020
- Издательство: Oxford University Press
- Местоположение издательства: United Kingdom
- Первая страница: 12534
- Последняя страница: 12555
- DOI: 10.1093/nar/gkaa1126
- Аннотация: Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences capable of forming G4 structures have been described based on in vitro analysis, and evidence supporting their formation in live cells continues to accumulate. While formation of DNA G4s (dG4s) within chromatin in vivo has been supported by different chemical, imaging and genomic approaches, formation of RNA G4s (rG4s) in vivo remains a matter of discussion. Recent data support the dynamic nature of G4 formation in the transcriptome. Such dynamic fluctuation of rG4 folding-unfolding underpins the biological significance of these structures in the regulation of RNA metabolism. Moreover, rG4-mediated functions may ultimately be connected to mechanisms underlying disease pathologies and, potentially, provide novel options for therapeutics. In this framework, we will review the landscape of rG4s within the transcriptome, focus on their potential impact on biological processes, and consider an emerging connection of these functions in human health and disease.
- Добавил в систему: Tsvetkov Vladimir Borisovich