Practical Synthesis of α-Perfluoroalkyl Cyclic Imines and Aminesстатья
Информация о цитировании статьи получена из
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Дата последнего поиска статьи во внешних источниках: 19 июля 2013 г.
Аннотация:A convenient and simple approach for the preparation of α-CF3 and α-C2F5 substituted pyrrolines, tetrahydropyridines, tetrahydroazepine is described. Claisen condensation of N-protected cyclic amides with esters of perfluorocarboxylic acids followed by deprotection and decarboxylation in acidic media leads to the desired products. Reduction of these imines permits to obtain 5-, 6-, and 7-membered cyclic amines with α-CF3 or α-C2F5 group in good to moderate overall yields.