Aggressive behavior: Genetic and physiological mechanismsстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 8 апреля 2022 г.
Аннотация:The paper presents a review of the literature on the genetic determination of intraspecific aggressive behavior, one of the most complex and universal forms of social behavior in animals on different rungs of the evolutionary ladder. We consider the existing experimental approaches and new opportunities based on recent molecular technologies. The comprehensive approach allows investigating the evolutionary, genetic, and biological roots of aggression and its manifestations under different environmental and social factors, as well as genetic predispositions. The social importance of the problem is noted. The review considers the phenomenology of aggression and mechanisms that stimulate or prevent it. It is supposed that the main social mechanism deterring aggression in a population is the dominance–subordination relationships. Neurobiological determinants of aggression and the role of hereditary factors in controlling aggressive behavior in animals and humans are considered. By the example of neurochemical brain changes in male mice exposed to repeated aggression in daily agonistic intermale interactions, we present the research model “from behavior to the gene.” It is noted in the discussion that the same genes that influence aggressiveness in human were revealed in the experimental studies in animals of different strains, as well as in knockout and transgenic animals. They include genes for transporters supporting serotonin reuptake and enzymes involved in the synthesis and catabolism of serotonin and catecholamines. In conclusion, we consider the prospects of transcriptome studies and problems of the epigenetic regulation of aggressive behavior.