Transcriptome of the Krushinsky-Molodkina Audiogenic Rat Strain and Identification of Possible Audiogenic Epilepsy-Associated Genes

Chuvakova, L.N.; Funikov, S.Y.; Rezvykh, A.P.; Davletshin, A.I.; Evgen’ev, M.B.; Litvinova, S.A.; Fedotova, I.B.; Poletaeva, I.I.; Garbuz, D.G.

Авторы: Chuvakova Lyubov N., Funikov Sergei Yu, Rezvykh Alexander P., Davletshin Artem I., Evgen’ev Michael B., Litvinova Svetlana A., Fedotova Irina B., Poletaeva Inga I., Garbuz David G.
Журнал: Frontiers in Molecular Neuroscience
Том: 14
Номер: November 2021
Год издания: 2021
Издательство: Frontiers Research Foundation
Местоположение издательства: Switzerland
Первая страница: 1
Последняя страница: 16
Номер статьи: 738930
DOI: 10.3389/fnmol.2021.738930
Аннотация: Audiogenic epilepsy (AE), inherent to several rodent strains is widely studied as amodel of generalized convulsive epilepsy. The molecular mechanisms that determinethe manifestation of AE are not well understood. In the present work, we comparedtranscriptomes from the corpora quadrigemina in the midbrain zone, which are crucialfor AE development, to identify genes associated with the AE phenotype. Three ratstrains without sound exposure were compared: Krushinsky-Molodkina (KM) strain(100% AE-prone); Wistar outbred rat strain (non-AE prone) and “0” strain (partially AE-prone), selected from F2 KM × Wistar hybrids for their lack of AE. The findings showedthat the KM strain gene expression profile exhibited a number of characteristics thatdiffered from those of the Wistar and “0” strain profiles. In particular, the KM rats showedincreased expression of a number of genes involved in the positive regulation of theMAPK signaling cascade and genes involved in the positive regulation of apoptoticprocesses. Another characteristic of the KM strain which differed from that of theWistar and “0” rats was a multi-fold increase in the expression level of the Ttr geneand a significant decrease in the expression of the Msh3 gene. Decreased expressionof a number of oxidative phosphorylation-related genes and a few other genes wasalso identified in the KM strain. Our data confirm the complex multigenic nature ofAE inheritance in rodents. A comparison with data obtained from other independentlyselected AE-prone rodent strains suggests some common causes for the formation ofthe audiogenic phenotype.
Добавил в систему: Федотова Ирина Борисовна

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Transcriptome of the Krushinsky-Molodkina Audiogenic Rat Strain and Identification of Possible Audiogenic Epilepsy-Associated Genesстатья Исследовательская статья

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