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Estrogen effects on the development of type 1 hypersensitivity responsesстатья Тезисы
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 8 декабря 2021 г.
- Авторы: Zmeeva E., Lyadov F.K., Yurshev Y.A.
- Журнал: Allergy
- Том: 76
- Номер: S110
- Год издания: 2021
- Издательство: Blackwell Publishing Inc.
- Местоположение издательства: United Kingdom
- Первая страница: 423
- Номер статьи: 834
- DOI: 10.1111/all.15095
- Аннотация: Background: The rapid increase in the prevalence of type 1 hyper-sensitivity diseases in developed countries, especially among female patients, cause much concern. Moreover, now there is no review that covers the relationship between increased estrogen levels and a large number of different type 1 hypersensitivity reactions, namely: asthma, conjunctivitis, rhinitis, anaphylaxis, angioedema (Quincke ' s edema), food allergies, atopic dermatitis. The purpose of this study is to make a systematic research of the scientific literature in the PubMed database on the subject of the effects of female sex hormones (estrogens) on the development of 1 type hypersensitivity reactions. Method: A systematic research of the scientific literature was held in PubMed database, used full texts. Results: We made sure that the endocrine system is closely related and with the immune system and may greatly affect its function-ing. Estrogens are shown to up- regulate antigen- specific antibody- producing cells, switch classes of IgE, increase degranulation of mast cells and basophils, hence immunologically favour the development of a TH2- response. Conclusion: Published data in the literature indicate a correlation between the level of circulating estrogen in the blood and the fre-quency and severit y of hypersensitivit y reactions, however, an exact determination of the mechanisms of their mutual influence requires further research. The authors hope that the data obtained in the re-search aim are promising and will be used by practitioners and immu-nologists for a more accurate diagnosis, as well as for more effective treatment of allergic reactions using the principles of personalized medicine.
- Добавил в систему: Змеева Екатерина Игоревна
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