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Effect of lithium chloride on mortality in ischemic stroke in ratтезисы доклада
- Авторы: Cherpakov R.A., Grebenchikov O.A., Ershov A.V., Shabanov A.K., Antonova V.V., Kuzovlev A.N.
- Сборник: 40th International Symposium on Intensive Care & Emergency Medicine 2021
- Серия: S1
- Том: 25
- Тезисы
- Год издания: 2021
- Место издания: Springer Science and Business Media LLC
- Первая страница: 41
- Последняя страница: 41
- Номер статьи: p103
- DOI: 10.1186/s13054-021-03769-1
- Аннотация: Introduction: The aim of the study was to evaluate the effect of lith- ium chloride in various dosages on mortality in ischemic stroke in rats. Methods: The study used male rats weighing 312 ± 12.5 g. The model of Long’s focal ischemia was used as a basis. The animals were split into 5 groups: false-operated, control (model of ischemic stroke with the introduction of 0.9% NaCl) and three groups in which the simula- tion of ischemic stroke was combined with the introduction of lithium chloride in various concentrations (4.2 mg/kg, 21 mg/kg and 63 mg/ kg, respectively). The drug was administered daily for 14 days. Daily, cumulative, and final mortality rates were evaluated. Results: According to the results of the experiment, the following data on mortality were obtained: false – operated rats – 0 out of 8, control group – 13 out of 22 (lethality 59%), group III (LiCl 4.2 mg/kg) – 8 out of 14 (lethality 57%), p > 0.05 relative to the control, group IV (LiCl 21 mg/kg) - 6 out of 15 (lethality 40%) p > 0.05 relative to the control and in group V (LiCl 63 mg/kg), 4 out of 15 animals died (lethality 27%) p = 0.0317 relative to the control. The highest mortality rate in the con- trol group was observed on day 1 (22.7%). In groups IV and V, the daily mortality rate was evenly distributed, in group III the largest number of animals died on day 3 (3 out of 14; 21.42%). The cumulative mor- tality rate in group III significantly differed from the control one only on day 2 (p < 0.05). In group IV, cumulative mortality was significantly lower up to 7 days (p < 0.05). In group V, cumulative mortality was sig- nificantly lower (p < 0.05) until 14 days after euthanasia. Conclusions: Long-term administration of lithium chloride at a dose of 63 mg/kg significantly reduced the mortality of laboratory animals after a stroke. The effect of the drug at a dose of 21 mg/kg was less pro- nounced. The dose of 4.2 mg/kg showed no neuroprotective effect.
- Добавил в систему: Черпаков Ростислав Александрович