Effect of the LKEKK Peptide on Human Keratinocytesстатья
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Дата последнего поиска статьи во внешних источниках: 1 декабря 2021 г.
Аннотация:Abstract—The LKEKK peptide (Np5) corresponding to the 16–20 sequence of thymosin-α1 (TM-α1) and to the 131–135 sequence of interferon-α2 (IFN-α2) and its [3H]Np5 analog were synthesized. [3H]Np5 was found to bond to human keratinocytes with high affinity and specificity (Kd 2.6 nM). Np5 dose-dependently decreased the inerleukin-17A-induced production of inflammatory cytokines (TNF-α, IL-6, and IL-1α) by on range from 50 to 1000 nM and increased a production of the anti-inflammatory IL-10 cytokine in vitro. The peptide effect was shown to be mediated through an activation of soluble guanylate cyclase.