Аннотация:Biosensors became one of the promising technologies in recent years. Wide applications and active development of related technologies lead to rising number of biosensors-related publications. A lot of them focused on the implantable biosensors that can help to operate future implantable medical devices. One of the main issues for implantable biosensors became power supply. In this chapter, several perspective approaches for the development of self-power biosensors are discussed. We have presented an overview of power generation approaches that can be applied in the case of implantable biosensors applications. It is worth mentioning that bioelectrochemical systems can be very powerful, but their influence on the organism is still not fully clear. Also, an overview of recent research in the field of electroconductive materials for implantable bioelectrochemical systems, with both biofuel cells and biosensors application, is presented. Moreover, a variety of approaches for material development from carbon nanomaterials to the polymeric systems have been described; and finally, some novel approaches for self-powered implantable systems are discussed.