Acetylcholine as a trigger of the somatic exocytosis in Retzius neurons

Авторы: Kazakova Tatiana A., Suchalko Oleg N., Ivanov Alexey D., Alova Anna V., Maksimov George V.
Журнал: bioRxiv (The preprint server for biology)
Год издания: 2020
DOI: 10.1101/2020.12.01.405951
Аннотация: The redistribution of vesicles containing serotonin in leech neurons wasstudied using the fluorescent, scanning ion-conductance, and laser phase microscopymethods. During acetylcholine receptor (AChR) activation in Retzius neurons, thechanges of Ca 2+ desorption, cellular stiffness and the cell optical phase difference(OPD) were established. It was found that the amplitude of OPD changes in the nearmembrane area (membrane and near-membrane of the cytoplasm layers) increasesupon AChR activation and this is, possibly, associated with the neurons vesicleredistribution. The decrease in the cell stiffness upon AChR activation suggests thecrucial role of cytoskeleton for vesicle transport and release. Ca2+ rise in thecytoplasm during AChR activation may regulate the mitochondrial recruitment toregions with high energy demand for vesicle trafficking
Добавил в систему: Алова Анна Владимировна

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