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Acidosis and the effect of Verigo-Bohr in the pathogenesis of COVID-19статья
- Авторы: Nechipurenko Yu D., Semyonov D.A., Lavrinenko I.A., Lagutkin D.A., Generalov E.A., Zaitseva A.Yu, Matveeva O.V., Egorov E.E.
- Сборник: International Congress devoted to the Memory of the Founders of Biophysics Department of Physics Faculty of Lomonosov Moscow State University – professor L.A. Blumenfeld and professor S.E. Shnoll
- Год издания: 2021
- Издательство: Globustar Formaat
- Местоположение издательства: Tallinn, Estonia
- Первая страница: 17
- Последняя страница: 17
- DOI: 10.52455/sbpr.02.202102
- Аннотация: A number of mechanisms linking the damaging factors of COVID-19 with acidosis have been considered, and the existence of positive feedbacks between the development of hypoxia and acidosis has been shown. In the early stages of the disease, inflammation, difficulty in gas exchange, thrombosis and other damage to the body bring the onset of acidosis closer. In accordance with the Verigo-Bohr effect, a decrease in blood pH leads to a decrease in saturation, which contributes to the further development of acidosis and leads to a deterioration in the patient's condition. A decrease in pH can also cause conformational changes in the S-protein of the virus and lead to a decrease in the affinity and avidity of antibodies.
- Добавил в систему: Генералов Евгений Александрович