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Quaternary ammonium derivatives of 2-aminothiophene-3-carboxylates with antimicrobial activityстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Дата последнего поиска статьи во внешних источниках: 3 февраля 2022 г.
- Авторы: Khachatryan D.S., Kolotaev A.V., Osipov V.N., Yashkir V.A., Matevosyan K.R.
- Сборник: AIP Conference Proceedings. Proceedings of the II International conference
- Том: 2063
- Год издания: 2019
- Место издания: AIP Publishing
- Номер статьи: 040023
- DOI: 10.1063/1.5087355
- Аннотация: Reaction of alkyl chlorides and N-benzylimidazole was conducted by refluxing them in dioxane. The synthesized product was characterized using 1H-NMR. The reaction yielded white solid quaternary ammonium salts (QAS) in 31-82%. QAS have been widely researched its activity as antimicrobial and antibacterial. The substitution of the functional groups on the QAS structure affects its biological activity. Antimicrobial activity of QAS was assayed by the method of serial twofold dilutions in a liquid nutrient medium. According to the results, QAS could potentially be developed as a new drug candidate for the treatment of microbial infections.
- Добавил в систему: Осипов Василий Николаевич