Development and Preclinical Studies of Orthotopic Bone Implants Based on a Hybrid Construction from Poly(3-Hydroxybutyrate) and Sodium Alginate

Muraev, A.A.; Bonartsev, A.P.; Gazhva, Y.V.; Riabova, V.M.; Volkov, A.V.; Zharkova, I.I.; Stamboliev, I.A.; Kuznetsova, E.S.; Zhuikov, V.A.; Myshkina, V.L.; Mahina, T.K.; Bonartseva, G.A.; Yakovlev, S.G.; Kudryashova, K.S.; Voinova, V.V.; Mironov, A.A.; Shaitan, K.V.; Gazhva, S.I.; Ivanov, S.Y.

Статья опубликована в журнале из списка RSCI Web of Science

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 6 февраля 2017 г.

Авторы: Muraev A.A., Bonartsev A.P., Gazhva Yu V., Riabova V.M., Volkov A.V., Zharkova I.I., Stamboliev I.A., Kuznetsova E.S., Zhuikov V.A., Myshkina V.L., Mahina T.K., Bonartseva G.A., Yakovlev S.G., Kudryashova K.S., Voinova V.V., Mironov A.A., Shaitan K.V., Gazhva S.I., Ivanov S.Yu
Журнал: Современные технологии в медицине
Том: 8
Номер: 4
Год издания: 2016
Первая страница: 42
Последняя страница: 50
DOI: 10.17691/stm2016.8.4.06
Аннотация: The aim of the investigation was to develop a technology of manufacturing bone implants based on a hybrid polymer construction composed of poly(3-hydroxybutyrate) and sodium alginate for guided bone regeneration using 3D printing method. Materials and Methods. Complex shaped bone implants based on poly(3-hydroxybutyrate) and sodium alginate were manufactured by the method of two-stage leaching using a mold obtained by 3D printing. The appearance, morphology and structure of the obtained scaffolds were analyzed by means of scanning electron microscopy. Biocompatibility in vivo was determined based on the histology data of scaffolds implantation as bone substitutes. Results. The study of the developed hybrid 3D scaffolds from poly(3-hydroxybutyrate) and sodium alginate showed that they perform a restrictive function providing conditions for regeneration of flat cranial bones in rats. Conclusion. The developed hybrid 3D scaffolds do not interfere with normal osteogenesis and provide beneficial conditions for regeneration.
Добавил в систему: Бонарцев Антон Павлович

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Development and Preclinical Studies of Orthotopic Bone Implants Based on a Hybrid Construction from Poly(3-Hydroxybutyrate) and Sodium Alginateстатья

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