Cyclometalated (NNC)Ru(ii) complex catalyzed beta-methylation of alcohols using methanol

Авторы: Ganguli Kasturi, Belkova Natalia V., Kundu Sabuj
Журнал: Dalton Transactions
Том: 51
Номер: 11
Год издания: 2022
Издательство: Royal Society of Chemistry
Местоположение издательства: United Kingdom
Первая страница: 4354
Последняя страница: 4365
DOI: 10.1039/d1dt03967a
Аннотация: Indolyl fragment containing phenanthroline based new ligands and their corresponding Ru(II) complexes were synthesized and fully characterized by various spectroscopic techniques. The catalytic activity of these newly synthesized cyclometalated (NNC)Ru(II) complexes was explored towards the β-methylation of alcohols using methanol. Notably, these complexes displayed superior reactivity compared to various (NNN)Ru(II) complexes. Utilizing this strategy, a wide range of primary, secondary, and aliphatic straight chain alcohols were selectively methylated. This protocol was further employed for the methylation of a few natural products and the gram scale synthesis of β-methylated alcohols. A series of control experiments and kinetic studies were performed to understand the plausible reaction mechanism.
Добавил в систему: Астахов Григорий Сергеевич

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