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Attenuated ADP-inhibition of FOF1 ATPase mitigates manifestations of mitochondrial dysfunction in yeastстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 20 апреля 2022 г.
- Авторы: Lapashina Anna S., Kashko Nataliia D., Zubareva Valeria M., Galkina Kseniia V., Markova Olga V., Knorre Dmitry A., Feniouk Boris A.
- Журнал: Biochimica et Biophysica Acta - Bioenergetics
- Год издания: 2022
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 148544
- DOI: 10.1016/j.bbabio.2022.148544
- Аннотация: Highlights•Mutation Gln263Leu in subunit β of mitochondrial ATP synthase from baker's yeast attenuates the non-competitive inhibition of the enzyme ATPase activity (ADP-inhibition) with no major effect on ATP production by mitochondria•The mutation resulted in a decrease of the yeast growth rate and extended the lag period before exponential growth when starved yeast were inoculated in a fresh growth medium.•The growth rate of yeast without mitochondrial DNA (ρ0) was increased by the mutation; the mutant ρ0 strain was less sensitive to ATP synthase inhibitor azide•ADP-inhibition might play a role in prevention of wasteful ATP hydrolysis in the mitochondrial matrix
- Добавил в систему: Фенюк Борис Александрович