Development of a Long-Acting Injectable Formulation of Rilpivirine Based On PLGA Microspheres

Авторы: Ulianova Yulia, Ermolenko Yulia, Trukhan Vladimir, Ivanov Vladimir, Iusupov Ildar, Kurkin Alexander, Gelperina Svetlana
Сборник: Proceedings of the 7th World Congress on Recent Advances in Nanotechnology (RAN’22)
Год издания: 2022
Место издания: Avestia Publishing
Первая страница: 1
Последняя страница: 6
Номер статьи: NDDTE 143
DOI: 10.11159/nddte22.143
Аннотация: The rilpivirine-loaded spherical and monodisperse PLGA microspheres were produced by microfluidic technology. The technological parameters such as the flow rate ratio and the rilpivirine/PLGA ratio were optimized to ensure desired microspheres size and higher encapsulation efficiency of rilpivirine. The microspheres exhibited a continuous drug release characterized by only a minor burst effect. These results suggest that the PLGA microspheres loaded with rilpivirine is a promising approach to the injectable depot formulation of this drug.
Добавил в систему: Ульянова Юлия Вячеславовна

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