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Novel tetrazole PtIIand PdIIcomplexes with enhanced water solubility: Synthesis, structural characterization and evaluation of antiproliferative activityстатья
- Авторы: Serebryanskaya T.V., Lyakhov A.S., Ivashkevich L.S., Grigoriev Y.V., Kritchenkov A.S., Khrustalev V.N., Tskhovrebov A.G., Ivashkevich O.A.
- Журнал: Zeitschrift für Kristallographie – Crystalline Materials
- Том: 236
- Номер: 1-2
- Год издания: 2021
- Издательство: Walter de Gruyter
- Местоположение издательства: Berlin, Germany
- Первая страница: 23
- Последняя страница: 32
- DOI: 10.1515/zkri-2020-0082
- Аннотация: Novel platinum(II) and palladium(II) chlorido complexes with tetrazole derivatives 1-(2-hydroxyethyl)tetrazole (het) and 1-[tris(hydroxymethyl)methyl]tetrazole (thm), viz. cis-[Pt(het)2Cl2], trans-[Pt(het)2Cl2], trans-[Pt(thm)2Cl2], trans-[Pd(het)2Cl2], and trans-[Pd(thm)2Cl2], were synthesized. The compounds were characterized by elemental and high-resolution electrospray ionization (HRESI) mass spectrometry, high-performance liquid chromatography (HPLC), 1H, 13C and 195Pt nuclear magnetic resonance (NMR) spectroscopy, thermal analyses, and Infrared (IR) spectroscopy. Molecular and crystal structures of trans-[PdL2Cl2] and trans-[PtL2Cl2] (L = het, thm) were established by single-crystal X-ray analysis. The complex cis-[Pt(het)2Cl2] was found to undergo cis-to-trans isomerization upon heating in acetonitrile solution and in the solid state. The synthesized complexes show rather high water solubility lying in the range of 2-10 mg/L. © 2020 Walter de Gruyter GmbH, Berlin/Boston.
- Добавил в систему: Цховребов Александр Георгиевич