Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain

Samsonova, A.; El, H.K.; Desforges, B.; Joshi, V.; Clément, M.; Lambert, G.; Henrie, H.; Babault, N.; Craveur, P.; Maroun, R.; Steiner, E.; Bouhss, A.; Maucuer, A.; Lyabin, D.; Ovchinnikov, L.; Hamon, L.; Pastré, D.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 апреля 2022 г.

Авторы: Samsonova A., El Hage K., Desforges B., Joshi V., Clément MJ, Lambert G., Henrie H., Babault N., Craveur P., Maroun RC, Steiner E., Bouhss A., Maucuer A., Lyabin DN, Ovchinnikov LP, Hamon L., Pastré D.
Журнал: Communications Biology
Том: 4
Год издания: 2021
Издательство: Springer Nature
Местоположение издательства: Switzerland
Номер статьи: 359
DOI: 10.1038/s42003-021-01862-3
Аннотация: The RNA-binding protein Lin28 (Lin28a) is an important pluripotency factor that reprograms translation and promotes cancer progression. Although Lin28 blocks let-7 microRNA maturation, Lin28 also binds to a large set of cytoplasmic mRNAs directly. However, how Lin28 regulates the processing of many mRNAs to reprogram global translation remains unknown. We show here, using a structural and cellular approach, a mixing of Lin28 with YB-1 (YBX1) in the presence of mRNA owing to their cold-shock domain, a conserved β-barrel structure that binds to ssRNA cooperatively. In contrast, the other RNA binding-proteins without cold-shock domains tested, HuR, G3BP-1, FUS and LARP-6, did not mix with YB-1. Given that YB-1 is the core component of dormant mRNPs, a model in which Lin28 gains access to mRNPs through its co-association with YB-1 to mRNA may provide a means for Lin28 to reprogram translation. We anticipate that the translational plasticity provided by mRNPs may contribute to Lin28 functions in development and adaptation of cancer cells to an adverse environment.
Добавил в систему: Лябин Дмитрий Николаевич

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Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domainстатья Исследовательская статья

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