High-pressure crystallography shows noble gas intervention into protein-lipid interaction and suggests a model for anaesthetic action

Melnikov, I.; Orekhov, P.; Rulev, M.; Kovalev, K.; Astashkin, R.; Bratanov, D.; Ryzhykau, Y.; Balandin, T.; Bukhdruker, S.; Okhrimenko, I.; Borshchevskiy, V.; Bourenkov, G.; Mueller-Dieckmann, C.; van der Linden, P.; Carpentier, P.; Leonard, G.; Gordeliy, V.; Popov, A.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 апреля 2022 г.

Авторы: Melnikov Igor, Orekhov Philipp, Rulev Maksim, Kovalev Kirill, Astashkin Roman, Bratanov Dmitriy, Ryzhykau Yury, Balandin Taras, Bukhdruker Sergei, Okhrimenko Ivan, Borshchevskiy Valentin, Bourenkov Gleb, Mueller-Dieckmann Christoph, van der Linden Peter, Carpentier Philippe, Leonard Gordon, Gordeliy Valentin, Popov Alexander
Журнал: Communications Biology
Том: 5
Номер: 1
Год издания: 2022
Издательство: Springer Nature
Местоположение издательства: Switzerland
Номер статьи: 360
DOI: 10.1038/s42003-022-03233-y
Аннотация: In this work we examine how small hydrophobic molecules such as inert gases interact with membrane proteins (MPs) at a molecular level. High pressure atmospheres of argon and krypton were used to produce noble gas derivatives of crystals of three well studied MPs (two different proton pumps and a sodium light-driven ion pump). The structures obtained using X-ray crystallography showed that the vast majority of argon and krypton binding sites were located on the outer hydrophobic surface of the MPs – a surface usually accommodating hydrophobic chains of annular lipids (which are known structural and functional determinants for MPs). In conformity with these results, supplementary in silico molecular dynamics (MD) analysis predicted even greater numbers of argon and krypton binding positions on MP surface within the bilayer. These results indicate a potential importance of such interactions, particularly as related to the phenomenon of noble gas-induced anaesthesia.
Добавил в систему: Орехов Филипп Сергеевич

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High-pressure crystallography shows noble gas intervention into protein-lipid interaction and suggests a model for anaesthetic actionстатья

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