Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cellsстатья
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Дата последнего поиска статьи во внешних источниках: 11 мая 2022 г.
Аннотация:Immunofluorescent microscopy of cancer cells A549 treated with novel alicyclic (mostly bridged) podophyllotoxin C4-esters at different concentrations gave evidence that the “curling” of microtubules takes place at one of the first steps of their depolymerization. Molecular dynamics study revealed the differences in curved conformations of tubulin dimer in a complex with adamantane-comprising ester and in a complex with podophyllotoxin.