Modeling the Co2+ Binding to Amyloid Peptide A beta 13-23 in Water Environment by NMR Spectroscopyстатья
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Дата последнего поиска статьи во внешних источниках: 11 мая 2022 г.
Аннотация:Alzheimer's disease is a fatal neurodegenerative disorder involving the abnormal accumulation and deposition of peptides (amyloid-beta, A beta) derived from the amyloid precursor protein. Various factors that cause pathology data are revealed, but, at the moment, there is no clear understanding of the processes of plaque formation. This is interesting and actual problem because metals such as zinc, manganese, and others induce A beta aggregation and fibril formation at high metal concentrations, while low concentration metal ions selectively destabilize the A beta oligomeric species. In present paper, we report a structural studies of the Co2+ ion binding sites of A beta fragments in water environment by 1D (H-1) and 2D (H-1-H-1) NMR spectroscopy. According to the observed changes in the NMR spectra that were determined, the cobalt binding center of the A beta(13-23) peptide is associated with the aspartate and glutamine residues. Structural model of cobalt associated with A beta peptide was obtained.