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Human mutagenesis in contextтезисы доклада
- Авторы: Alexander Panchin, Sergey Mitrofanov, Sergey Spirin, Andrey Alexeevski, Yuri Panchin
- Сборник: Proceedings of Moscow Conference on Computational Molecular Biology (MCCMB'11)
- Тезисы
- Год издания: 2011
- Место издания: Москва
- Первая страница: 274
- Последняя страница: 275
- Аннотация: A cytosine followed by a guanine (CG) is the most known example of a nucleotide word within the human genome with a dramatically increased probability to undergo mutation. Specific DNA methyltransferase enzymes convert cytosines in CG dinucleotides into methyl-cytosines, which are eventually prone to turn into thymine as a result of deamination. The discovery of other nucleotide contexts that have profound effects on substitution rates can improve our understanding of mutation processes. We compared rates of inherited mutations in 1-4bp nucleotide contexts using reconstructed ancestral states of human single nucleotide polymorphisms (SNPs) from intergenic regions. Chimp and orangutan genomic sequences were used for the purpose of outgroups.
- Добавил в систему: Митрофанов Сергей Игоревич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Сборник тезисов | en_mccmb_2011.pdf | 6,4 МБ | 15 февраля 2017 [Mitrofanov] |
| 2. | Краткий текст | Тезисы | en_mccmb_2011.274-275.pdf | 327,5 КБ | 15 февраля 2017 [Mitrofanov] |