|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Adoptive Immunotherapy Based on Chain-Centric TCRs in Treatment of Infectious Diseasesстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Kalinina A.A., Nesterenko L.N., Bruter A.V., Balunets D.V., Chudakov D.M., Izraelson M., Britanova O.V., Khromykh L.M., Kazansky D.B.
- Журнал: iScience
- Том: 23
- Номер: 12
- Год издания: 2020
- Издательство: Cell Press
- Местоположение издательства: United States
- Аннотация: Complications after vaccination, lack of vaccines against certain infections, and the emergence of antibiotic-resistant microorganisms point to the need for alternative ways of protection and treatment of infectious diseases. Here, we proposed a therapeutic approach to control salmonellosis based on adoptive cell therapy. We showed that the T cell receptor (TCR) repertoire of salmonella-specific memory cells contains 20% of TCR variants with the dominant-active α-chain. Transduction of intact T lymphocytes with the dominant salmonella-specific TCRα led to their enhanced in vitro proliferation in response to salmonella. Adoptive transfer of transduced T cells resulted in a significant decrease in bacterial loads in mice infected with salmonella before or after the adoptive transfer. We demonstrated that adoptive immunotherapy based on T cells, transduced with dominant-specific TCRα could be successfully applied for treatment and prevention of infectious diseases and represent a useful addition to vaccination and existing therapeutic strategies.
- Добавил в систему: Калинина Анастасия Андреевна