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Poly(vinyl alcohol)-based cryogels loaded with the poly(3-hydroxybutyrate) microbeads and the evaluation of such composites as the delivery vehicles for simvastatinстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 1 июня 2022 г.
- Авторы: Michurov D.A., Makhina T.K., Siracusa V., Bonartsev A.P., Lozinsky V.I., Iordanskii A.L.
- Журнал: Polymers
- Том: 14
- Номер: 11
- Год издания: 2022
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 2196
- DOI: 10.3390/polym14112196
- Аннотация: Highly porous composite poly(vinyl alcohol) (PVA) cryogels loaded with the poly(3-hydroxybutyrate) (PHB) microbeads containing the drug, simvastatin (SVN), were prepared viacryogenic processing (freezing—storing frozen—defrosting) of the beads’ suspensions in aqueous PVA solution. The rigidity of the resultant composite cryogels increased with increasing the filler content. Optical microscopy of the thin section of such gel matrices revealed macro-porous morphologyof both continuous (PVA cryogels) and discrete (PHB-microbeads) phases. Kinetic studies ofthe SVN release from the drug-loaded microbeads, the non-filled PVA cryogel and the composite material showed that the cryogel-based composite system could potentially serve as a candidate for the long-term therapeutic system for controlled drug delivery. Such PHB-microbeads-containingPVA-cryogel-based composite drug delivery carriers were unknown earlier; their preparation and studies have been performed for the first time.
- Добавил в систему: Лозинский Владимир Иосифович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | полный текст статьи | Crst_60_Polymers_2022_Michurov.pdf | 1,5 МБ | 31 мая 2022 [Lozinskii] |