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Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Modelстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Sze Wah Wong Sarah, Krylov Vadim B., Argunov Dmitry A., Karelin Alexander A., Bouchara Jean-Phillipe, Fontaine Thierry, Latgé Jean-Paul, Nifantiev Nikolay E.
- Журнал: mSphere
- Том: 5
- Номер: 1
- Год издания: 2020
- DOI: 10.1128/msphere.00688-19
- Аннотация: Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide.
- Добавил в систему: Лопухов Антон Владимирович