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Протективная активность поликлональных и моноклональных антител к липополисахариду Neisseria meningitidis серогруппы А в экспериментах in vitroстатья
Статья опубликована в журнале из списка RSCI Web of Science
Статья опубликована в журнале из перечня ВАКСтатья опубликована в журнале из списка Web of Science и/или Scopus
- Авторы: Дельвиг А.А., Краснопрошина Л.И., Волгарева Г.М., Бобылева Г.В., Кувакина В.И., Артемьева Т.А.
- Журнал: Журнал микробиологии, эпидемиологии и иммунобиологии
- Номер: 10
- Год издания: 1990
- Первая страница: 118
- Последняя страница: 121
- Аннотация: The protective activity of the sera of mice immunized with the preparations of native and detoxified N. meningitidis lipopolysaccharide (LPS), group A, as well as with monoclonal antibodies to N. meningitidis antigens, groups A and B, was studied on the mucin model of meningococcal infection. The study showed that the maximum level of anti-LPS antibodies in mice was observed on day 7 after the injection of LPS. Immune sera obtained from mice were capable of protecting the animals from fetal meningococcemia induced by N. meningitidis strains of homologous and heterologous groups. As shown by the results of this study, the alkaline treatment of N. meningitidis native LPS did not decrease the protective properties of antibodies. The monoclonal antibodies under study were found to possess high preventive activity in mice challenged with N. meningitidis, groups A and B. Anti-LPS monoclonal antibodies showed greater protective activity than antipolysaccharide monoclonal antibodies.
- Добавил в систему: Волгарева Галина Михайловна