Toxicological properties of 7-methylguanine, and preliminary data on its anticancer activity

Авторы: Kirsanov K., Fetisov T., Antoshina E., Trukhanova L., Gor’kova T., Vlasova O., Khitrovo I., Lesovaya E., Kulbachevskaya N., Shcherbakova T., Belitsky G., Yakubovskaya M., Švedas V., Nilov D.
Журнал: Frontiers in pharmacology
Год издания: 2022
Издательство: Frontiers Media]
Местоположение издательства: [Lausanne, Switzerland
DOI: 10.3389/fphar.2022.842316
Аннотация: 7-Methylguanine (7-MG) competitively inhibits the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) and RNA-modifying enzyme tRNA-guanine transglycosylase (TGT) and represents a potential anticancer drug candidate. Furthermore, as a natural compound, it could escape the serious side effects characteristic for approved synthetic PARP inhibitors. Here we present a comprehensive study of toxicological and carcinogenic properties of 7-MG. It was demonstrated that 7-MG does not induce mutations or structural chromosomal abnormalities, and has no blastomogenic activity. A treatment regimen with 7-MG has been established in mice (50 mg/kg per os, 3 times per week), exerting no adverse effects or changes in morphology. Preliminary data on the 7-MG anticancer activity obtained on transplantable tumor models support our conclusions that 7-MG can become a promising new component of chemotherapy.
Добавил в систему: Нилов Дмитрий Константинович

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