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Study of the mechanism of reactions catalyzed by the cytochrome c complex with cardiolipin activated by coumarin dyesтезисы доклада
- Авторы: Levchenko I.N., Volodyaev I.V., Boyarchenkov A.S.
- Сборник: «Биоинформатика регуляции и структуры генома/Системная биология»
- Серия: 13
- Тезисы
- Глава в коллективной монографии
- Год издания: 2022
- Место издания: ICG SB RAS Novosibirsk
- Первая страница: 221
- Последняя страница: 222
- Номер статьи: 122
- DOI: 10.18699/SBB-2022-122
- Аннотация: Modern technologies and programming tools make it possible not to simply solve the problem, but also, using simulation and complex modeling methods, to create a virtual reality for work in which researchers can consider the topic of interest in all its diversity . Here we analytically solved kinetic equations, describing the oxychemiluminescent reactions in the suspension of mitochondrial membranes, and compared the obtained results with experimental data . The system contained cytochrome c, forming a complex with cardiolipin, activated by the coumarin dye C-525 during apoptosis. The free radical formation was constantly monitored via the oxychemiluminescence kinetics. For data analysis, we developed a special program to calculate reaction rate constants based on the known reaction scheme, and compare different calculation algorithms.
- Добавил в систему: Левченко Ирина Николаевна