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Gene Expression Asymmetry in the Human Prefrontal Cortexстатья
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 13 июля 2022 г.
- Авторы: Efimova Olga, Pavlov Konstantin, Kachanovskiy Mark, Ayupova Asiya, Zorkina Yana, Morozova Anna, Andreyuk Denis, Kostyuk Georgiy
- Сборник: Advances in Cognitive Research, Artificial Intelligence and Neuroinformatics
- Серия: Advances in Cognitive Research, Artificial Intelligence and Neuroinformatics. Proceedings of the 9th International Conference on Cognitive Sciences, Intercognsci-2020, October 10-16, 2020, Moscow, Russia
- Том: 1358
- Год издания: 2021
- Издательство: Springer International Publishing AG
- Местоположение издательства: Cham, Switzerland
- Первая страница: 464
- Последняя страница: 472
- DOI: 10.1007/978-3-030-71637-0_53
- Аннотация: Advanced interhemispheric asymmetry considered to be a unique feature of the human brain. However, studies of the human brain asymmetry at the gene expression level are scarce and report contradictory results. In total, three healthy control and four schizophrenia adult human bilateral Brodmann area 10 (BA10) samples were used in the experiment. FOS, PDK4, CD44, and AQP1 genes had differential expression in the right and left BA10 in HC as revealed by RT-qPCR. In SZ FOS only showed differential expression. For the first time, a decrease of interhemispheric asymmetry of FOS, PDK4, CD44, and AQP1 gene expression in BA10 of schizophrenia patients was revealed. We propose that it might play a key role in the cognitive and social maladaptation. Immunohistochemistry revealed that Aqp1 localized in the GFAP-positive astrocytes of the infragranular cortical layers. Close proximity of AQP1-positive astrocytic endfeets to the cerebral vessels implies their participation in neurovascular coupling. Thus, our results are in good agreement with the hypothesis that evolutionarily novel mechanisms of brain functioning are disrupted in neuropsychiatric diseases.
- Добавил в систему: Костюк Георгий Петрович