Аннотация:The electrochemical thiocyanation of barbituric acids with NH4SCN was disclosed in an undivided cell
under constant current conditions. The electrosynthesis is the most efficient at a record high current
density ( janode ≈50–70 mA cm−2
). NH4SCN has a dual role as the source of the SCN group and as the
electrolyte. Electrochemical thiocyanation of barbituric acids starts with the generation of (SCN)2 from
the thiocyanate anion. The addition of thiocyanogen to the double bond of the enol tautomer of barbitu-
ric acid gives thiocyanated barbituric acid. A variety of thiocyanated barbituric acids bearing different func-
tional groups were obtained in 18–95% yields and were shown to exhibit promising antifungal activity.