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Gender-Related Aspects in Osteoarthritis Development and Progression: A Reviewстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Peshkova Maria, Lychagin Alexey, Lipina Marina, Matteo Berardo Di, Anzillotti Giuseppe, Ronzoni Flavio, Kosheleva Nastasia, Shpichka Anastasia, Royuk Valeriy, Fomin Victor, Kalinsky Eugene, Timashev Peter, Kon Elizaveta
- Журнал: International Journal of Molecular Sciences
- Том: 23
- Номер: 5
- Год издания: 2022
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 2767
- DOI: 10.3390/ijms23052767
- Аннотация: Osteoarthritis (OA) is a common degenerative joint disease treated mostly symptomatically before approaching its definitive treatment, joint arthroplasty. The rapidly growing prevalence of OA highlights the urgent need for a more efficient treatment strategy and boosts research into the mechanisms of OA incidence and progression. As a multifactorial disease, many aspects have been investigated as contributors to OA onset and progression. Differences in gender appear to play a role in the natural history of the disease, since female sex is known to increase the susceptibility to its development. The aim of the present review is to investigate the cues associated with gender by analyzing various hormonal, anatomical, molecular, and biomechanical parameters, as well as their differences between sexes. Our findings reveal the possible implications of gender in OA onset and progression and provide evidence for gaps in the current state of art, thus suggesting future research directions.
- Добавил в систему: Тимашев Петр Сергеевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Gender-Related_Aspects_in_Osteoarthritis_Development_and_Pr… | 9,2 МБ | 3 августа 2022 [TPS_SU] |