Cryostructuring of Polymeric Systems: 62 Preparation and Characterization of Alginate/Chondroitin Sulfate Cryostructurates Loaded with Antimicrobial Substances

Vernaya, O.I.; Ryabev, A.N.; Shabatina, T.I.; Karlova, D.L.; Shabatin, A.V.; Bulatnikova, L.N.; Semenov, A.M.; Melnikov, M.Y.; Lozinsky, V.I.

Авторы: Vernaya Olga I., Ryabev Andrey N., Shabatina Tatyana I., Karlova Daria L., Shabatin Andrey V., Bulatnikova Lyudmila N., Semenov Alexander M., Melnikov Mikhail Ya, Lozinsky Vladimir I.
Журнал: Polymers
Том: 14
Номер: 16
Год издания: 2022
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 3271
DOI: 10.3390/polym14163271
Аннотация: Targeted drug release is a significant research focus in the development of drug deliverysystems and involves a biocompatible polymeric carrier and certain medicines. Cryostructuring is asuitable approach for the preparation of efficient macroporous carriers for such drug delivery systems.In the current study, the cryogenically structured carriers based on alginate/chondroitin sulfatemixtures were prepared and their physicochemical properties and their ability to absorb/release thebactericides were evaluated. The swelling parameters of the polysaccharide matrix, the amount ofthe tightly bound water in the polymer and the sulfur content were measured. In addition, FTIRand UV spectroscopy, optical and scanning microscopy, as well as a standard disk diffusion methodfor determining antibacterial activity were used. It was shown that alginate/chondroitin sulfateconcentration and their ratios were significant factors influencing the swelling properties and theporosity of the resultant cryostructurates. It was demonstrated that the presence of chondroitin sulfatein the composition of a polymeric matrix slowed down the release of the aminoglycoside antibioticgentamicin. In the case of the NH2-free bactericide, dioxidine, the release was almost independent ofthe presence of chondroitin sulfate. This trend was also registered for the antibacterial activity testsagainst the Escherichia coli bacteria, when examining the drug-loaded biopolymeric carriers.
Добавил в систему: Лозинский Владимир Иосифович

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Cryostructuring of Polymeric Systems: 62 Preparation and Characterization of Alginate/Chondroitin Sulfate Cryostructurates Loaded with Antimicrobial Substancesстатья

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