Аннотация:The article is devoted to the study of the association of different genotypes of genes of serotonin receptor 5-HT2A (HTR2A) and dopamine receptor subtype D4 (DRD4) with the peculiarities of the emotional and personal sphere of Russian boys and girls. The work was attended by Russian boys and girls, psychology students, in the amount of 100 people. The study aimed to study the association of different HTR2A and DRD4 gene genotypes with emotional and personal characteristics of Russian boys and girls living in the South of Russia. The following methods were used: Test of emotional intelligence (D.V. Lyusin); Emotional Empathy Questionnaire (A. Mehrabian, N. Epstein); «Big five» test; Toronto Alexithymia Scale. For statistical processing of the results obtained, multivariate analysis of variance ANOVA with Tukey's post hoc analysis for non-equilibrium sample sizes was applied. According to the results of the study, based on the analysis of variance, no data were obtained on the association of different genotypes of the HTR2A and DRD4 genes in terms of the characteristics of the emotional and personal spheres. However, based on the use of Tukey's a posteriori analysis for non-equilibrium samples, the differences between Russian boys and girls, carriers of different genotypes of the HTR2A and DRD4 genes, are described in terms of the characteristics of the emotional and personal spheres, such as empathy, alexithymia, and personality traits that are included in the Big Five personality traits factors.