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The Influence of Lipid Matrix Composition on the Microenvironment of Levofloxacin in Liposomal Formsстатья Исследовательская статья
- Авторы: Le-Deygen Irina, Safronova Anastasia, Kolmogorov Ilya, Skuredina Anna, Kudryashova Elena
- Журнал: Russian Journal of Bioorganic Chemistry
- Том: 48
- Номер: 4
- Год издания: 2022
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 710
- Последняя страница: 719
- DOI: 10.1134/S1068162022040148
- Аннотация: We have studied the interaction of the antibacterial drug levofloxacin with lipid bilayers of variouscompositions: 100% DPPC and with the addition of 20% cardiolipin. For DPPC liposomes, levofloxacin wasfound to penetrate into the subpolar region at the lipid–water interface. The role of the anionic lipid in theinteraction of an active molecule with a bilayer has been established: levofloxacin enters the microenvironmentof the phosphate group, displacing water, and does not penetrate into the hydrophobic part of thebilayer. For the first time, the study of the microenvironment of levofloxacin in the liposome by IR and CDspectroscopy was carried out. Such an approach based on a combination of several spectral methods opensup new prospects for the creation of new medicinal properties and the possibility of predicting the nature ofthe interaction of active molecules with biomembranes in order to predict their efficacy and potential sideeffects.
- Добавил в систему: Ле-Дейген Ирина Михайловна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | RJBC710.pdf | 779,2 КБ | 20 августа 2022 [i.m.deygen] |