|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Nanocomposite Based on a Natural Anionic Polysaccharide for Anticancer Drug Immobilizationстатья
- Авторы: Spiridonov Vasily, Shibaeva Anna, Kusaia Victoriia, Zoirova Zukhra, Antonova Yulia, Yaroslavov Alexander
- Журнал: Macromolecular Symposia
- Том: 404
- Номер: 1
- Год издания: 2022
- Издательство: John Wiley & Sons Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 2100297
- DOI: 10.1002/masy.202100297
- Аннотация: Synthesis of polymer nanocomposite as nanocontainers for doxorubicin (DOX) is carried out at a molar ratio of monomer units of the anionic polysaccharide (sodium hyaluronate) and Ca2+-ions as a cross-linking agent equaled to 10/1. Highly water-soluble white fibrous products can be prepared. The hydrodynamic diameter of nanocompsite (Ca2+/Na-Hyaluronate) particles is equal to 150 nm. At the same time, diameter of the original sodium hyaluronate (Na-Hyaluronate) macromolecules is about 300 nm. The interaction between synthesized nanocomposite particles, Ca2+/Na-Hyaluronate, and DOX accompanied by a new complex formation can be confirmed by means of fluorimetry. Obtained results indicate that the nanocomposite is capable as an immobilizing doxorubicin nanocontainer.
- Добавил в систему: Кусая Виктория Сергеевна