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N-Glycosides of substituted, indolo[2,3-a]carbazolesстатья
- Авторы: Melnik Stalina Yakovlevna, Bakhmedova A.A., Ektova L.V., Garaeva L.D., Goryunova O.V., Miniker T.D., Plikhtyak I.L., Yartseva I.V.
- Сборник: Abstracts of Papers, 16th Int, Congr. of Heterocyclic Chemistry
- Год издания: 1997
- Место издания: Bozeman MT, USA
- Первая страница: OII
- Последняя страница: 164
- Аннотация: 1-(2,3,5-Tri-O-acetyl)-β-D-ribofuranosyl indole, the key compound in the synthesis of glycosides with the bis(indole) aglycone, was obtained for the first time by the indoline–indole method. There were synthesized 3-(1-methylindol-3-yl)-4-(1-glycosylindol-3-yl)furan(or pyrrole)-2,5-diones containing the residue of β-D-ribofuranose or 2-deoxy-β-D-ribofuranose and analogous glycosides of indolo[2,3-a]furano(or pyrrolo)[3,4-с]carbazol-5,7-diones, which are structurally relative to the antitumor antibiotic rebeccamycin. Their cytotoxicities toward a number of human tumor cell lines were studied in vitro, and the carbazole N-glycosides were shown to be more active than the bis(indole) glycosides. At the same time, the ribofuranosides were found to be less active than the corresponding ribopyranosides synthesized previously
- Добавил в систему: Пугачева Ружена Борисовна