Аннотация:Chamenerin-I (Oenothein B), isolated from plant raw materials of fireweed of narrow-leaved Chamaenerion angustifolium (L.) is a dimeric macrocyclic tannin, among similar oligomers, trimeric and tetramer tannins, it is most active [1]. Chamenerin-I and related oligomeric ellagitannins exhibit various physiological activities in vitro or in vivo. We identified and described the properties of dimeric and trimeric ellagitannins isolated from shoots and inflorescences of Chamaenerion angustifolium. In in vitro studies, macrocyclic trimeric ellagitannins “2” (compound of a new type containing an oxide cycle) and II (Oenothein A), as well as a monosodium derivative of dimeric macrocyclic tannin - Chamenerin-I showed cytotoxic activity against kidney cancer SN-12, A498, breast cancer SK-BR-3, A549 adenocarcinoma, and hepatocellular carcinoma (Hep-2G). At the same time, the studied ellagitannins exhibit a greater cytotxic effect on tumor cell lines than on normal human fibroblasts. The cytotoxicity mechanism of ellagitannins was studied using A549 cell lines and is associated with induction of apoptosis. ellagitannins caused a decrease in the migration activity of A549 tumor cells when examined by the method of wound healing and reduction of the formation of spheroids after 48 hours of cultivation with ellagitannins.