Fluoride Additive as a Simple Tool to Qualitatively Improve Performance of Nickel-Catalyzed Asymmetric Michael Addition of Malonates to Nitroolefins

Авторы: Afanasyev Oleg, Kliuev Fedor, Tsygankov Alexey, Nelyubina Yulia, Gutsul Evgenii, Novikov Valentin, Chusov Denis
Журнал: Journal of Organic Chemistry
Том: 87
Номер: 18
Год издания: 2022
Издательство: American Chemical Society
Местоположение издательства: United States
Первая страница: 12182
Последняя страница: 12195
DOI: 10.1021/acs.joc.2c01339
Аннотация: Nowadays, design of the new chiral ligands for organometallic catalysts is often based on the step-by-step increase in their complexity to improve efficiency. Herein we describe that simple in situ addition of the fluoride source to the asymmetric organometallic catalyst can improve not only activity but also enantioselectivity. Bromide–nickel diimine complexes were found to catalyze asymmetric Michael addition in low yields and ee, but activation with fluoride leads to a significant improvement in catalyst performance. The developed approach was applied to prepare several enantioenriched GABA analogues.
Добавил в систему: Афанасьев Олег Ильич

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ИНХС РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА