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Amyloidogenic Peptides: New Class of Antimicrobial Peptides with the Novel Mechanism of Activityстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Galzitskaya Oxana V., Kurpe Stanislav R., Panfilov Alexander V., Glyakina Anna V., Grishin Sergei Y., Kochetov Alexey P., Deryusheva Evgeniya I., Machulin Andrey V., Kravchenko Sergey V., Domnin Pavel A., Surin Alexey K., Azev Viacheslav N., Ermolaeva Svetlana A.
- Журнал: International Journal of Molecular Sciences
- Том: 23
- Номер: 10
- Год издания: 2022
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 5463
- DOI: 10.3390/ijms23105463
- Аннотация: Antibiotic‐resistant bacteria are recognized as one of the leading causes of death in the world. We proposed and successfully tested peptides with a new mechanism of antimicrobial action “protein silencing” based on directed co‐aggregation. The amyloidogenic antimicrobial peptide (AAMP) interacts with the target protein of model or pathogenic bacteria and forms aggregates, thereby knocking out the protein from its working condition. In this review, we consider antimicrobial effects of the designed peptides on two model organisms, E. coli and T. thermophilus, and two pathogenic organisms, P. aeruginosa and S. aureus. We compare the amino acid composition of proteomes and especially S1 ribosomal proteins. Since this protein is inherent only in bacterial cells, it is a good target for studying the process of co‐aggregation. This review presents a bioinformatics analysis of these proteins. We sum up all the peptides predicted as amyloidogenic by several programs and synthesized by us. For the four organisms we studied, we show how amyloidogenicity correlates with antibacterial properties. Let us especially dwell on peptides that have demonstrated themselves as AMPs for two pathogenic organisms that cause dangerous hospital infections, and in which the minimal inhibitory concentration (MIC) turned out to be comparable to the MIC of gentamicin sulfate. All this makes our study encouraging for the further development of AAMP. The hybrid peptides may thus provide a starting point for the antibacterial application of amyloidogenic peptides.
- Добавил в систему: Галзитская Оксана Валериановна