Surface measurements of cingulate gyrus and memory in normal agingстатьяТезисы
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 29 мая 2015 г.
Аннотация:In the present study we investigated the relationships between the surface areas of different subparts within the cingulate cortex and memory performance in healthy elderly subjects. . Factor analysis showed three groups of neuropsychological indexes that were significantly correlated with the surface of target Broadman fields.
1. Factor 1 relates to immediate and delayed memory recall for both verbal and visuospatial material. This factor showed positive correlation with the surface of the right BA 23 (r = 0.71, p < .01).
2. Factor 2 is associated with the better performance on the delayed memory recall after the subjects performed a distractor motor task. It was independent from confabulations, order errors and intrusions in the immediate recall tests. This factor might reflect directed search in memory after switching from one task to another. High loads on this factor correlated with greater surface of right BA 26 and right BA 29 (r = 0.53 and r = 0.52, p <.05, respectively).
3. Factor 3 had positive loadings for the scores on the implicit memory tasks and negative loadings on the delayed verbal and visuospatial tests. This factor structure positively correlated with surface of left BA 29 and left BA 30 (r = 0.47 and r = 0.72, p < .05, respectively).
Taken together, these results support the relationship between neuropsychological indexes of aging and the structure of the posterior cingulate and retrosplenial regions. The surface area of the cingulate subparts might be used as an additional marker for dementia screening.