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Nodal asymmetry and hedgehog signaling during vertebrate left–right symmetry breakingстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Negretti Maria Isabella, Böse Nina, Petri Natalia, Kremnyov Stanislav, Tsikolia Nikoloz
- Журнал: Frontiers in Cell and Developmental Biology
- Том: 10
- Год издания: 2022
- Издательство: Frontiers Media S.A.
- Местоположение издательства: Lausanne, Switzerland
- Первая страница: 1
- Последняя страница: 9
- DOI: 10.3389/fcell.2022.957211
- Аннотация: Development of visceral left–right asymmetry in bilateria is based on initialsymmetry breaking followed by subsequent asymmetric molecular patterning.An important step is the left-sided expression of transcription factor pitx2 whichis mediated by asymmetric expression of the nodal morphogen in the left lateralplate mesoderm of vertebrates. Processes leading to emergence of theasymmetric nodal domain differ depending on the mode of symmetrybreaking. In Xenopus laevis and mouse embryos, the leftward fluid flow onthe ventral surface of the left–right organizer leads through intermediate stepsto enhanced activity of the nodal protein on the left side of the organizer andsubsequent asymmetric nodal induction in the lateral plate mesoderm. In thechick embryo, asymmetric morphogenesis of axial organs leads to paraxialnodal asymmetry during the late gastrulation stage. Although it was shown thathedgehog signaling is required for initiation of the nodal expression, themechanism of its asymmetry remains to be clarified. In this study, weestablished the activation of hedgehog signaling in early chick embryos tofurther study its role in the initiation of asymmetric nodal expression. Our datareveal that hedgehog signaling is sufficient to induce the nodal expression incompetent domains of the chick embryo, while treatment of Xenopus embryosled to moderate nodal inhibition. We discuss the role of symmetry breaking andcompetence in the initiation of asymmetric gene expression.
- Добавил в систему: Кремнёв Станислав Валерьевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Текст статьи | fcell-10-957211.pdf | 1,9 МБ | 13 сентября 2022 [Kremnyov] |
| 2. | Полный текст | Текст статьи | fcell-10-957211_XK8eXyh.pdf | 1,9 МБ | 13 сентября 2022 [Kremnyov] |