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Selection of Mice for Object Permanence Cognitive Task Solution. 2022, 14,696–706статья
- Авторы: Perepelkina O.V., Poletaeva I.I.
- Журнал: Neurology International
- Том: 14
- Номер: 3
- Год издания: 2022
- Издательство: PagePress
- Местоположение издательства: Italy
- Первая страница: 696
- Последняя страница: 706
- DOI: 10.3390/neurolint14030058
- Аннотация: The selection of mice for high (“plus”) and low (“minus”) scores in the puzzle-box test wasperformed over five generations. This test evaluates the success (or failure) in finding the underpass,leading to the dark part of the box, when it is blocked. This means that the mouse is either able orunable to operate the “object permanence rule” (one of the index’s cognitive abilities). For the “+”strain, animals were bred who solved the test when the underpass test blocked with a plug; the “−”strain comprised those who were unable to solve this task. In mice of the “+” strain, the proportion ofanimals that was able to solve “plug” stages of the test was higher than in the “−” strain and in thenon-selected genetically heterogeneous population. The “+” mice ate significantly more new food inthe hyponeophagia test. Animals of both strains demonstrated the ability to “manipulate” the plugblocking the underpass, touching the plug with their paws and muzzle, although the majority of “−”mice were unable to open the underpass effectively. Thus, mice of both selected strains demonstratedthat they were able to understand that the underpass does exist, but only “+”-strain animals (at leastthe majority of them) were able to realize the solution. The selection for plug-stage solution successaffected the mouse’s ability to open the hidden underpass.
- Добавил в систему: Перепелкина Ольга Викторовна