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Methylation status of telomerase reverse transcriptase and telomerase RNA genes in Danio rerio at different agesтезисы доклада
Информация о цитировании статьи получена из
Web of Science
Дата последнего поиска статьи во внешних источниках: 27 мая 2015 г.
- Авторы: Belova E., Kozlov A., Zvereva M., Dontsova O.
- Сборник: FEBS Journal
- Серия: Issue Supplement s1
- Том: 280
- Тезисы
- Год издания: 2013
- Место издания: St.Petersburg, Russia
- Первая страница: 22
- Последняя страница: 22
- DOI: 10.1111/febs.12340
- Аннотация: Gene expression often depends on the methylation status of the regulatory region of the gene. DNA methylation may affect chro- matin compactization and prevent the binding of transcription factors. We analyze the methylation status of CpG islands inside and near telomerase reverse transcriptase (TERT) and telomerase RNA (TR) genes in Danio rerio at different ages. We found that the regulatory region of the TERT gene (from 1500 to 0 bp) is methylated almost entirely, while the initial region of the gene (from 0 to 500 bp) is unmethylated. Besides, the methylation pat- tern does not depend neither on age nor the place in different organs. Similarly, the entire TR gene is unmethylated in all cases. It is interesting that the methylation status of the region right after the end of the TR gene depends on age. Thus, we believe that it is possible to regulate the transcription termination of this non-coding RNA using methylation.
- Добавил в систему: Зверева Мария Эмильевна