Strontium Substituted b-Tricalcium Phosphate Ceramics: Physiochemical Properties and Cytocompatibility

Fadeeva, I.V.; Deyneko, D.V.; Forysenkova, A.A.; Morozov, V.A.; Akhmedova, S.A.; Kirsanova, V.A.; Sviridova, I.K.; Sergeeva, N.S.; Rodionov, S.A.; Udyanskaya, I.L.; Antoniac, I.V.; Rau, J.V.

Авторы: Fadeeva Inna V., Deyneko Dina V., Forysenkova Anna A., Morozov Vladimir A., Akhmedova Suraya A., Kirsanova Valentina A., Sviridova Irina K., Sergeeva Natalia S., Rodionov Sergey A., Udyanskaya Irina L., Antoniac Iulian V., Rau Julietta V.
Журнал: Molecules
Том: 27
Номер: 18
Год издания: 2022
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 6085
DOI: 10.3390/molecules27186085
Аннотация: Sr2+-substituted β-tricalcium phosphate (b-TCP) powders were synthesized using the mechano-chemical activation method with subsequent pressing and sintering to obtain ceramics. The concentration of Sr2+ in the samples was 0 (non-substituted TCP, as a reference), 3.33 (0.1SrTCP), and 16.67 (0.5SrTCP) mol.% with the expected Ca3(PO4)2, Ca2.9Sr0.1(PO4)2, and Ca2.5Sr0.5(PO4)2 formulas, respectively. The chemical compositions were confirmed by the energy-dispersive X-ray spectrometry (EDX) and the inductively coupled plasma optical emission spectroscopy (ICP-OES) methods. The study of the phase composition of the synthesized powders and ceramics by the powder X-ray diffraction (PXRD) method revealed that β-TCP is the main phase in all compounds except 0.1SrTCP, in which the apatite (Ap)-type phase was predominant. TCP and 0.5SrTCP ceramics were soaked in the standard saline solution for 21 days, and the phase analysis revealed the partial dissolution of the initial β-TCP phase with the formation of the Ap-type phase and changes in the microstructure of the ceramics. The Sr2+ ion release from the ceramic was measured by the ICP-OES. The human osteosarcoma MG-63 cell line was used for viability, adhesion, spreading, and cytocompatibility studies. The results show that the introduction of Sr2+ ions into the β-TCP improved cell adhesion, proliferation, and cytocompatibility of the prepared samples. The obtained results provide a base for the application of the Sr2+-substituted ceramics in model experiments in vivo.
Добавил в систему: Дейнеко Дина Валерьевна

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Strontium Substituted b-Tricalcium Phosphate Ceramics: Physiochemical Properties and Cytocompatibilityстатья

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