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YB-1 protein: functions and regulationстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Lyabin D.N., Eliseeva I.A., Ovchinnikov L.P.
- Журнал: Wiley interdisciplinary reviews. RNA
- Том: 5
- Номер: 1
- Год издания: 2014
- Издательство: Wiley
- Местоположение издательства: Singapore
- Первая страница: 95
- Последняя страница: 110
- DOI: 10.1002/wrna.1200
- Аннотация: The Y-box binding protein 1 (YB-1, YBX1) is a member of the family of DNA- and RNA-binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into a group of intrinsically disordered proteins that do not follow the classical rule 'one protein-one function' but introduce a novel principle stating that a disordered structure suggests many functions. YB-1 participates in a wide variety of DNA/RNA-dependent events, including DNA reparation, pre-mRNA transcription and splicing, mRNA packaging, and regulation of mRNA stability and translation. At the cell level, the multiple activities of YB-1 are manifested as its involvement in cell proliferation and differentiation, stress response, and malignant cell transformation.
- Добавил в систему: Лябин Дмитрий Николаевич