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Simulation of the Sorting of Two Types of Cells in a Cell Spheroid with Account for the Movement of The Boundaries of Regions Occupied by Cells of Different Typesстатья
- Автор: Logvenkov S.A.
- Журнал: Fluid Dynamics
- Том: 57
- Номер: 6
- Год издания: 2022
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 796
- Последняя страница: 810
- DOI: 10.1134/S0015462822601152
- Аннотация: The cultivation of cell aggregates obtained by mixing cells of different types, in particularembryonic ones, leads to their sorting, i.e., the formation of cell structures that are characterized bythe spatial separation of large groups of cells of different types, separated from each other by wellobserved boundaries. Typical are cell structures in which a compact mass of cells of one type is surroundedby cells of another type. In the present study, the problem of redistribution of the densities oftwo types of cells that form a cell spheroid is formulated and investigated. The problem formulationuses the previously proposed continuum model of a biological continuum [Logvenkov S.A., Stein A.A.Fluid Dynamics 2022. V. 57, No. 3, P. 221] formed by two actively interacting cell phases and a fluid.Problems are solved that use two types of boundary conditions taking into account the possible movementof the outer boundaries of areas occupied by cells of different types: in one case, both boundariesare considered to coincide, and in the other, the possibility of their independent movement is allowed.The influence of local and nonlocal laws of development of active intercellular interactions on thesorting process is studied. The properties of the solutions are analyzed for both problem formulations.It is shown that solutions of the problem with two independently moving boundaries describe moreadequately the phenomenon of sorting, when cells with stronger contracting active interactions tendto occupy the central region, displacing cells with weaker contracting interactions. Solutions of theproblem with two boundaries are more stable relative to perturbations of the initial conditions. Fordescribing this process, both nonlocal and local models can be used.
- Добавил в систему: Логвенков Сергей Алексеевич