Cytotoxicity of electrophilic iron(II) clathrochelates in human promyelocytic leukemia cell lineстатья
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Дата последнего поиска статьи во внешних источниках: 26 марта 2017 г.
Аннотация:promyelocytic leukemia cells (IC50 = 6.5 ± 4.6 lM), which correlates with the enhancement of
intracellular oxidative stress (17-fold increase with respect to the cells treated with the solvent only). Based on in vitro studies we suggested that this effect is caused by alkylation of glutathione leading to inhibition of the cellular antioxidative system and by catalytic generation of reactive oxygen species by products of the alkylation reaction.