Comparison between the Results of the Gas Chromatography–MassSpectrometry Analysis of Solutions of the Silyl Derivatives of DriedExhaled Breath Condensate Samples from Patients with BronchialAsthma and COPD and Healthy Volunteers

Авторы: Revel’skii A.I., Samokhin A.S., Anaev E.Kh
Журнал: Journal of Analytical Chemistry
Том: 77
Номер: 11
Год издания: 2022
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 1553
Последняя страница: 1560
DOI: 10.1134/S1061934822110090
Аннотация: Exhaled breath condensate (EBC) as a test material in metabolomic studies continues to receivethe attention of analysts. The exhaled air condensate is a sample whose composition reflects the characteristicsof biochemical processes in the body; this is a relatively pure matrix, as compared to blood, which containsmore polar components (including nonvolatile ones) unlike exhaled air. In addition, EBC sampling isnoninvasive. The silylation products of lyophilized EBC samples from healthy volunteers and patients withbronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) were studied using gas chromatography–mass spectrometry with electron ionization. The total ion current chromatograms correspondingto the samples of BA and COPD patients exhibited silyl derivatives of mono-D-fructose and disaccharides.It was hypothesized that D-fructose can be a marker of biochemical processes occurring in the patients diagnosedwith BA and COPD.
Добавил в систему: Ревельский Александр Игоревич

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ИНХС РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА